A symposium
called "Genetics and
the Human Genome Project:
Where
Scientific and Public
Cultures Meet"
was organized by Joan
H Fujimura and
held at Stanford U
on November 3 and
4. The first day was
devoted principally
to the Human Genome
Diversity Proj-
ect, and the second
to the Human
Genome Project and
its attendant
issues.
Speaking on
behalf of the HGDP
were lawyer Hank Greely
(Stanford),
geneticist Kenneth
Kidd (Yale), and
anthropologist John
Moore (Florida).
Of these, Moore's
talk was the most
unfamiliar to followers
of HGDP pub-
licity. Moore
emphasized the ephemer-
ality and cultural
basis of ethnic classi-
fications, in defiance
of the overall
sampling strategy
of the project, but
nevertheless concluded
that the HGDP
would be able to solve
significant ques-
tions of human biological
history.
Moore's criticism
was cast in bold
relief when the next
speaker, geneticist
Frank Dukepoo (Northern
Arizona),
was introduced as
"a full-blooded
Hopi" -- and Dukepoo
proceeded to
explain that his mother
is Laguna, and
that his genetic ancestry
is actually
considerably more
motley than a sim-
ple cultural designation
would lead one
to believe.
No one,
interestingly enough, raised
the recent Nature
editorial (377:183,
1995), which had made
a startling rec-
ommendation.
"With physical anthro-
pology under a cloud
for its habit of
using measurable skeletal
indices as
proxies for less tangible
attributes (cra-
nial capacity as a
measure of intelli-
gence, for example),
it would be better
to invest what goodwill
there is in
some quite different
field. The Human
Genome Diversity Project
is already
battling to win the
consent of distinc-
tive racial groups
to schemes for col-
lecting and analysing
DNA." When the
leading science journal
in the world
recommends the reinvestment
of good-
will from physical
anthropology to the
HGDP, it should be
taken as a very
ominous portent, especially
since the
same arguments for
the reinvestment of
"goodwill" will hold
for the reinvest-
ment of "federal funding"
and anything
else.
Nature
was obliged to modify its
position the following
week (377:372,
1995), when the HGDP
was roundly
rebuffed by UNESCO's
ethics board
(377:373, 1995).
A subsequent letter
(from your humble
correspondent) also
noted that Nature's
characterization of
physical anthropology
does not seem to
have been influenced
by any develop-
ments since the last
world war
(377:570, 1995).
At any rate, at the Stanford meeting,
I spoke generally
about the implica-
tions of the history
of American genet-
ics. and more specifically
about genet-
ics providing scientific
justifications
for "folk" views of
social issues. The
HGDP fits nicely into
this mold,
reflecting the conceptions
of anthropol-
ogy as seen by molecular
population
geneticists.
Anthropologists were
added only as an afterthought,
with the
promise of a ride
on the gravy train --
and the field has
not been able to influ-
ence the fundamental
policies of the
HGDP substantially.
This obviously
bodes poorly for the
intellectual
integrity of the project,
and for the
advancement of anthropology
thereby.
Hank Greely
agreed that the
HGDP's problems have
been largely
their own fault, but
objected that the
quotations I was displaying
and criti-
cizing from their
published corpus
were outdated, some
going as far back
as 1990-91.
Apparently the publica-
tions and proclamations
of the HGDP
are not intended to
have a particularly
lengthy shelf life.
Much of the
discussion centered
around the natural
and culturally con-
structed variation
in the human
species -- the relationship
between bio-
logical demes and
social races-which
had been raised as
well by other speak-
ers: Troy Duster (Berkeley),
Eric
Juengst (Case Western)
and Renato
Rosaldo (Stanford).
The second
day was devoted to "the
homosexuality gene" and
other issues
generally relating to genetics
in Ameri-
can society. Dean
Hamer (NIH) pre-
sented his work on the greater-than-
random association of homosexual
male sib-pairs with a set
of genetic
markers on chromosomal region
Xq28.
Neil Risch (Stanford) proceeded
to
demonstrate that the association
was
not significantly different
from ran-
dom, being instead the result
of the
greater-than-random exclusion
of sib-
ships that did not fit the
expectations.
Janet Halley (Stanford)
also raised
political and legal issues
surrounding
the potential hard wiring
of sexual ori-
entation.
David Cox (Stanford)
explained the
significance of the 5% of
the HGP's
budget devoted to ELSI --
ethical, legal
and social implications
of the Human
Genome Project. Paul Billings
(Stan-
ford) discussed inequities
of health
insurance stemming from
genotypic
information. By the
afternoon, the
paradigmatic example had
shifted from
the "homosexuality gene'
-- which may
or may not exist -- to BRCAI,
a "breast
cancer susceptibility gene"
which does
exist, and whose issues
were detailed
by Nancy Press (Irvine)
The final talk was
also the most
provocative, by sociologist
Barbara
Katz Rothman (CUNY), who
raised the
question most people have
shied away
from: Why, in an era of
austerity, is the
Human Genome Project virtually
the
only contemporary scientific
endeavor
not feeling the pinch?