Meeting Notes

       A symposium called "Genetics and
     the Human Genome Project: Where
     Scientific and Public Cultures Meet"
     was organized by Joan H Fujimura and
     held at Stanford U on November 3 and
     4. The first day was devoted principally
     to the Human Genome Diversity Proj-
     ect, and the second to the Human
     Genome Project and its attendant
     issues.
       Speaking on behalf of the HGDP
     were lawyer Hank Greely (Stanford),
     geneticist Kenneth Kidd (Yale), and
     anthropologist John Moore (Florida).
     Of these, Moore's talk was the most
     unfamiliar to followers of HGDP pub-
     licity.  Moore emphasized the ephemer-
     ality and cultural basis of ethnic classi-
     fications, in defiance of the overall
     sampling strategy of the project, but
     nevertheless concluded that the HGDP
     would be able to solve significant ques-
     tions of human biological history.
     Moore's criticism was cast in bold
     relief when the next speaker, geneticist
     Frank Dukepoo (Northern Arizona),
     was introduced as "a full-blooded
     Hopi" -- and Dukepoo proceeded to
     explain that his mother is Laguna, and
     that his genetic ancestry is actually
     considerably more motley than a sim-
     ple cultural designation would lead one
     to believe.
        No one, interestingly enough, raised
     the recent Nature editorial (377:183,
     1995), which had made a startling rec-
     ommendation.  "With physical anthro-
     pology under a cloud for its habit of
     using measurable skeletal indices as
     proxies for less tangible attributes (cra-
     nial capacity as a measure of intelli-
     gence, for example), it would be better
     to invest what goodwill there is in
     some quite different field. The Human
     Genome Diversity Project is already
     battling to win the consent of distinc-
     tive racial groups to schemes for col-
     lecting and analysing DNA."  When the
     leading science journal in the world
     recommends the reinvestment of good-
     will from physical anthropology to the
     HGDP, it should be taken as a very
     ominous portent, especially since the
     same arguments for the reinvestment of
     "goodwill" will hold for the reinvest-
     ment of "federal funding" and anything
     else.
        Nature was obliged to modify its
     position the following week (377:372,
     1995), when the HGDP was roundly
     rebuffed by UNESCO's ethics board
     (377:373, 1995).  A subsequent letter
     (from your humble correspondent) also
     noted that Nature's characterization of
     physical anthropology does not seem to
     have been influenced by any develop-
     ments since the last world war
     (377:570, 1995).
         At any rate, at the Stanford meeting,
     I spoke generally about the implica-
     tions of the history of American genet-
     ics. and more specifically about genet-
     ics providing scientific justifications
     for "folk" views of social issues.  The
     HGDP fits nicely into this mold,
     reflecting the conceptions of anthropol-
     ogy as seen by molecular population
     geneticists.  Anthropologists were
     added only as an afterthought, with the
     promise of a ride on the gravy train --
     and the field has not been able to influ-
     ence the fundamental policies of the
     HGDP substantially.  This obviously
     bodes poorly for the intellectual
     integrity of the project, and for the
     advancement of anthropology thereby.
       Hank Greely agreed that the
     HGDP's problems have been largely
     their own fault, but objected that the
     quotations I was displaying and criti-
     cizing from their published corpus
     were outdated, some going as far back
     as 1990-91.  Apparently the publica-
     tions and proclamations of the HGDP
     are not intended to have a particularly
     lengthy shelf life.
       Much of the discussion centered
     around the natural and culturally con-
     structed variation in the human
     species -- the relationship between bio-
     logical demes and social races-which
     had been raised as well by other speak-
     ers: Troy Duster (Berkeley), Eric
     Juengst (Case Western) and Renato
     Rosaldo (Stanford).
       The second day was devoted to "the
    homosexuality gene" and other issues
    generally relating to genetics in Ameri-
    can society.  Dean Hamer (NIH) pre-
    sented his work on the greater-than-
    random association of homosexual
    male sib-pairs with a set of genetic
    markers on chromosomal region Xq28.
    Neil Risch (Stanford) proceeded to
    demonstrate that the association was
    not significantly different from ran-
    dom, being instead the result of the
    greater-than-random exclusion of sib-
    ships that did not fit the expectations.
    Janet Halley (Stanford) also raised
    political and legal issues surrounding
    the potential hard wiring of sexual ori-
    entation.
       David Cox (Stanford) explained the
    significance of the 5% of the HGP's
    budget devoted to ELSI -- ethical, legal
    and social implications of the Human
    Genome Project. Paul Billings (Stan-
    ford) discussed inequities of health
    insurance stemming from genotypic
    information.  By the afternoon, the
    paradigmatic example had shifted from
    the "homosexuality gene' -- which may
    or may not exist -- to BRCAI, a "breast
    cancer susceptibility gene" which does
    exist, and whose issues were detailed
    by Nancy Press (Irvine)
      The final talk was also  the most
    provocative, by sociologist Barbara
    Katz Rothman (CUNY), who raised the
    question most people have shied away
    from: Why, in an era of austerity, is the
    Human Genome Project virtually the
    only contemporary scientific endeavor
    not feeling the pinch?

    [on to Ken Kidd's indignant letter]